Which patient condition would most likely be associated with a history of syncopal episodes and a short PR interval?

Wolff-Parkinson-White (WPW) syndrome is a condition characterized by the presence of an accessory conduction pathway in the heart, which can lead to episodes of rapid heart rates and arrhythmias. One of the hallmark features of WPW syndrome is a short PR interval on an electrocardiogram (ECG), which results from the premature activation of the ventricles due to this additional pathway.

Patients with WPW syndrome are also at risk for developing paroxysmal supraventricular tachycardia, which can lead to syncopal episodes. This occurrence is attributed to the instances where rapid heartbeat causes hemodynamic compromise, resulting in loss of consciousness. Therefore, the combination of a history of syncopal episodes along with a short PR interval strongly suggests the presence of WPW syndrome.

In contrast, conditions like hypertrophic cardiomyopathy (HCM) and AV block do not typically present with a short PR interval. HCM may be associated with syncopal episodes due to obstructive dynamics, but it features longer PR intervals due to impaired conduction. Bradycardia indicates a slow heart rate, which alone would not explain the combination of syncopal episodes and a short PR interval.