Which coronary vessel is most commonly associated with ST elevation in V1, V2, and V3?

The left anterior descending (LAD) artery is most commonly associated with ST elevation in leads V1, V2, and V3 due to its anatomical position and the territories it supplies. The LAD primarily supplies the anterior wall of the left ventricle, as well as the interventricular septum. When there is an occlusion in the LAD, it can lead to anterior myocardial ischemia or infarction, which manifests as ST elevation in these specific leads on an electrocardiogram (ECG).

In this scenario, leads V1, V2, and V3 correspond to the anterior aspect of the heart. The significance of the LAD in the context of ST elevation is that any injury to the anterior wall due to LAD obstruction will reflect in these leads, providing critical information about the location of the cardiac insult. This is essential for both the diagnosis and management of acute coronary syndromes, where rapid identification of the artery involved can guide treatment strategies. The prominent role of the LAD in anterior myocardial infarctions makes it the correct answer to the question regarding which coronary vessel is associated with ST elevation in these leads.